Description
Product Characteristics:
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR125 (G protein-coupled receptor 125), also known as PGR21 or TEM5L, is a 1,321 amino acid multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and the LN-TM7 subfamily. Considered a novel orphan adhesion-type G-protein-coupled receptor, GPR125 has five leucine rich repeats (LRR), an immunoglobulin (Ig) domain and a GPS domain. GPR125 may play a functional role in choroidal and hippocampal response to brain injury. It is also suggested that GPR125 may be a marker for spermatogonial stem cells. Four isoforms of GPR125 exists due to alternative splicing events.
Subcellular location: Cell membrane
Synonyms: FLJ38547, G protein coupled receptor 125, PGR21, Probable G protein coupled receptor 125 precursor, TEM5 like, TEM5L, GP125_HUMAN, GPCR125.
Target Information: This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]